When Spider-Man and his allies attempt to track down the missing and dangerous Lizard, they discover that Venom has returned to seek revenge on the earth.
Spider-Man discovers Norman Osborn is responsible for the Venom Symbiote's escape; Norman, aka the Dark Goblin, brings the Generations team to battle against Spider-Man.
Symbiotes from space send an advanced hunting party to Earth to take out all of the superheroes; Spider-Man must team up with Marc Spector and Max Modell to save the planet.
When Toddler Groot lands on Earth to deliver an urgent warning, Spider-Man must decode the message and keep him out of the evil clutches of both A.I.M. and Baron Mordo.