Conrad is pulled away from celebrating Gigi’s 6th birthday when Sammie comes into Chastian with a 104-degree fever, and Kit must call in a favor for treatment. Meanwhile, a heart arrives for Governor Betz’s transplant surgery.
The ER quickly fills up after a heavy storm causes a devastating helicopter crash. Conrad, Devon and the rest of the Chastain doctors rush to treat patients including the helicopter pilot, a barista, and Chastain’s least favorite person, Governor Mark Betz.
A famous cardiothoracic surgeon – who happens to be Dr. Yamada’s mentor – comes into Chastain after experiencing heart pain. Meanwhile, Kit breaks the news that the ER will no longer be accepting trauma patients due to budget cuts, and Devon and Conrad help treat a confused woman.
Conrad comes face to face with Nic's dad, Kyle, after 5 years of no contact, when he comes into Chastain with an extremely low heart rate. Billie advises her patient against surgery, but the patient’s family ignores her recommendation. Meanwhile, Cade musters up the courage to confront Ian about his addiction and Leela grows concerned about Padma.
Devon is approached by a documentary producer as he prepares to perform the first titanium rib cage implant surgery in the country with Raptor, who must scramble to find a babysitter before the procedure. Meanwhile, Conrad tends to an unhelpful patient who claims to have been mauled by a large cat, and Dr. Bell faces negative press.
After a teenage boy is taken into Chastain for falling unconscious from a suspicious pill, Conrad takes action to find the boy's brother before he meets the same fate. Meanwhile, Dr. Bell deals with being served court papers from a former patient.
When a prison doctor believes a death row inmate is lying about his symptoms, Conrad and Raptor are called in to examine him. Meanwhile, Devon sees a traveling British couple who are nervous about the cost of American healthcare, and Kit and Bell meet with the Georgia Governor.
On the day of Kit and Bell’s wedding, Bell and Conrad get pulled away to tend to the ill daughter of a major hospital donor. Meanwhile, Billie takes Gigi and Sammie dress shopping.
A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.
Ian is faced with performing a surgery on a Jane Doe NICU patient while he continues to struggle with his personal issues. Meanwhile, Conrad asks Devon to cover his shift so he can spend a day at home with an anxious Gigi.
When a gunshot victim comes into the ER, his injuries prove to be so catastrophic throughout his body that multiple doctors need to jump on the case. Meanwhile, Ian is faced with a mandatory drug test and Padma prepares for her C-section.
The high stakes governor election results in violence at the polls, causing multiple victims to arrive at Chastain. Conrad finds common ground with an aggressive patient, helping lead to a diagnosis for his outbursts. Meanwhile, when another patient’s lung collapses, the doctors find a serious root of the issue.
When Padma's pregnancy takes a dangerous turn, the doctors come together to find a solution and turn to Ian to perform a miracle. Meanwhile, Conrad makes a decision regarding his love life and Devon leads his own clinical trials at Chastain.
