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The true story of the dramatic, high-stakes FBI manhunt for Ramirez Resendez, a dangerous Mexican serial killer who snuck across the border to travel by freight train to his random kill sites throughout the southern United States.

In December 1999, six Cuban inmates at the St. Martinville prison in Louisiana, used homemade knives to take several guards hostage, and then used the guards to take over the prison control room. They demanded to be freed or sent back to Cuba on the premise that they had finished serving sentences for their crimes but were being held in legal limbo -- immigration wanted to deport them, and the U.S. has no extradition treaty with Cuba.