Van der Valk and the team are called in when a scientist researching a potential breakthrough in the treatment of cancer is found dead. Van der Valk's ex-flame Kalie Tenkers returns to help the team investigate why he was killed and if there is a link to pharmaceutical billionaire Freddie Klink.

The team is called in when an environmental campaigner is murdered on the eve of a global conference. One of several potential suspects would appear to be Cobie Stegenga, a famous singer who went missing and is presumed dead. Van Der Valk connects with Cobie's father to find out the truth.

Van der Valk and his team return to investigate new crimes in Amsterdam. In addition to solving murder cases, Van der Valk has to deal with an unwelcome past romance resurfacing as well as find a way to make one of his beloved team members confront their own mortality.