The fate of the lab is at stake as the gang is held hostage by their new boss.
Reeling from Pristine's betrayal, Septico advertises for her replacement and is visited by a seemingly perfect candidate.
All the gang get painful and gross skin conditions when Pristine attempts to cover her spying by helping Septico get into the record books for the world's biggest blister.
A monstrous Fatberg emerges from the sewers to wreak havoc on the lab!
Septico and the gang try to stop the O'Cleans from destroying the world's Mite population by creating an ad campaign to show that microscopic mites are actually cool.
When it's revealed that Durp-E is secretly keeping a pet rat in the Yuck Lab, everyone is shocked as to whom the cringing, shrieking aversion to them is.
Leonidis' locks down the lab when his favorite stinky sandwich gets stolen, so Septico has to expose the gang to various stinky animals to find the culprit.
Septico's fascination with cockroaches causes chaos when he invites a specialist cockroach trainer to the lab.
Septico and Pristine seem to swap personalities after they're stung by zombie parasite wasps.
When the lab is overrun by an ant colony, Septico and the team have to bargain with the ants - before the O'Cleans can send in the Cleaners!
Septico's quest to do the perfect poop brings an ancient and dangerous curse on the lab.
A horrible, hairy monster is unleashed as Septico's arch-nemesis arrives for an inspection of the Yuck Lab.
When Pristine comes down with an increasingly more disgusting series of yucky conditions - Septico must save her from her body's own disgustingness.
The lab gang is left in charge of an annoying little girl with a tummy ache, as they scramble to prepare their submission for the World Yuckology Expo.
When a crew of pirate parasites takes over the Yuck Lab and infects the gang, Septico has to figure out a cure for the various parasites.
After Pristine turns down the chance to give a prestigious speech, Septico finds out she passed because she has urine control issues, and he's determined to whip her bladder in shape for her to give the speech.
When Septico's college crush, Botany "expert" Egregious Flytrap visits the lab, the gang tries to impress her with various disgusting plants, not realizing she wants to use those plants in a diabolical experiment.
Septico challenges World Fart Champion Gastrov Flatulinsky to a farting competition.
When Septico's long lost brother comes to visit, he's repulsed by the grossness of the Yuck Lab - until he accidentally gets turned into a poop loving housefly.
Septico's quest to take his body odor to new stinktacular heights forces Pristine to redesign her latest invention, the Smell-O-Vac, for her...
Septico tries his hand at wormcharming and Pristine hides a toothache when their dentist Aunt comes to visit.
Pristine's fear of fungus could destroy the lab.
Septico's attempt to throw Pristine a birthday party turns into a disgusting food eating competition.
A horrible, hairy monster is unleashed as Septico's arch-nemesis arrives for an inspection of the Yuck Lab.
When Septico's long lost brother comes to visit, he's repulsed by the grossness of the Yuck Lab - until he accidentally gets turned into a poop loving housefly.
A new recruit changes the dynamics in the lab as Snot Faucet's cold threatens a sticky end for everyone!
