When the 20-year-old clerk of an Atlanta-area smoke shop is gunned down during a robbery, investigators use a videotaped confession to smoke out the killers.

A family mourns the unexpected death of a beloved grandmother at Christmas, and while local police assure everyone that she was the victim of a tragic accident, some things about the scene don't add up.

A 33-year-old West Virginia husband and father seemingly dies in an accidental house fire; a closer look at the scene reveals a more sinister case.

A Texas love triangle turns deadly, and it appears to be an open-and-shut case until technology tells the tale.

July 4th weekend leads to a tragedy for a California family. To catch a killer, detectives utilize an unorthodox technique—analyzing bug fragments—to help put a murderer behind bars.

After the discovery of the brutal murder of an 18-year-old desk clerk of a beachfront condo, analysts use brand-new mitochondrial DNA technology to prove the killer's identity.

A young mother is found murdered in her home and there are two suspects with ample motive, but an unusual interview and security camera footage have investigators puzzled.

A young Colorado mother suddenly vanishes on Thanksgiving, but when police trace her cell phone, it leads them to a surprising character with an even more surprising story.

California police are baffled when an innocent man's DNA is found at the scene of a deadly home invasion, and authorities team with the man's defense attorney.

Eight days after she had disappeared on her way to a family ski trip, an 18-year-old young woman's partially nude body is found floating in a river in Wyoming. Years later, DNA technology uncovers dark secrets that led to her demise.

An upscale apparel store in Bethesda, MD, is the site of a gruesome scene when an employee is killed and her co-worker is battered and tied up, but surveillance video and blood evidence shed further light on the crime.

A true-crime enthusiast may connect a Jane Doe to a missing persons case in Ohio.